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Low Testosterone Latest Updates (August 2010)
Noticias De la Salud
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Publicado 03 September 2010 - Zeta-Jones,furiosa con los médicos de Douglas
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Publicado 02 September 2010
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Types of testosterone therapy available
| Preparations | Way used | Advantages | Disadvantages |
|---|---|---|---|
| Depot Injection Therapy | Injected deep intramuscularly (IM) every 1 to 4 weeks (usually in the buttocks) | • Testosterone absorbed directly into bloodstream | • Requires regular IM injections • Fluctuating levels of testosterone with high initial levels • Mood swings as testosterone levels rise and fall (“roller coaster” effect) • Local pain on injection • Abscess formation (rare) |
| Long-acting Injection Therapy | Injected IM every 3 months following an initial loading dose to stabilise testosterone levels | • Testosterone absorbed directly into blood stream • Infrequent dosing • Provides a steady level of testosterone • Avoids peaks and troughs over the day • Fewer adverse events such as mood swings or blood changes |
• Local pain on injection • Abscess formation (rare) |
| Implant Therapy | Small pellets of testosterone are placed under the skin (usually in the stomach or buttocks) under local anesthetic | • Infrequent dosing - usually required twice a year • Testosterone levels remain stable for up to 6 months as the pellets are slowly absorbed |
• May be pain and/or local infection at the site where pellets are inserted • Special equipment and minor surgical procedure required • Occasionally a pellet is expelled by the body • Scars after pellet removal |
| Gels | A clear testosterone gel rubbed onto the shoulders, chest or back once a day – dries within a few minutes. Testosterone is released steadily from the skin into the bloodstream over a 24-hour period | • Convenient sites of application • Quickly normalizes testosterone levels • Stable blood levels of testosterone throughout the day • Less skin irritation than patches • No operation needed |
• Skin irritation may be a rare side effect • Potential for transfer to partner or child |
| Patches | Applied to various areas of the skin (generally on a non-hairy part of the upper body) | • Efficient – steady absorption of testosterone over 24 hour period | • May not achieve levels of testosterone as effective as other preparations, such as gels • High chance of skin irritation • May be inconvenient to apply and can be dislodged |
| Oral Therapy | Forms of testosterone taken orally as pills or capsules – not recommended for long-term replacement of testosterone | • Convenient | • Considerable variation in absorption of dose • Should be taken with a fat-containing meal • Testosterone has to be in an altered form so that it is not broken down by the liver • One such form (testosterone undecenoate) has to be taken 2 or 3 times a day to maintain adequate levels • Another form (methyl testosterone) produces harmful side effects including liver damage and elevated cholesterol levels |
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