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Multiple sclerosis target uncovered
02 Apr 2008
Scientists have taken a significant step towards further understanding of multiple sclerosis (MS) by finding a potential new target for therapy.
Spanish researchers have demonstrated the role of a protein called collagenase-2 in the development of the disease through tests using mice.
Collagenase-2 is a member of a family of proteins called matrix metalloproteinases (MMPs, of which collagenase is MMP8) which help to break down collagen and other parts of bodily tissues.
It is believed that MMPs contribute to MS by degrading tissue that maintains a barrier between the blood and brain, allowing unwanted cells to invade and break down nerves.
MMPs are found in high levels in the blood and spinal fluid of people living with MS.
The research, published in JBC online, looked at two analyses of MMP8 to assess the role of the protein in the development of MS.
Scientists developed mutant mice deficient in the gene for MMP8, finding that they had fewer invading cells in the brain and fewer damaged nerves.
They then gave diseased mice a drug to block MMP8 activity and found that this reduced the severity of disease symptoms.
Researchers now believe that the findings show evidence of MMP8's role in the development of MS and offer up a new target for MS therapy.
Click here to learn more about multiple sclerosis
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