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30 Sep 2008
A chemical which helps to calm immune cells is more profuse in the spinal fluid of people who have multiple sclerosis (MS), it has been noted.
In news which may have implications for the treatment of people living with MS, the abundance of the protein TREM-2 boosts suspicion that it may be an important contributor to the condition.
Researchers from US academic institution Washington University School of Medicine suggest that while more of an immune controlling protein could seem like a positive thing for MS sufferers, TREM-2 is not in the right place to reduce aggression in such cells.
The symptoms of MS are caused by misdirected immune attacks on the protective lining that coasts branches of nerve cells, the scientists explain.
Lead author Dr Laura Piccio stated TREM-2 has only previously been seen on the surface of immune cells.
"In the new study, we found it floating freely in spinal fluid.
"This is only speculation for now, but these 'free agent' copies of TREM-2 could be making it harder for the TREM-2 that is attached to immune cells to keep the cells' aggressiveness under control," she added.
According to the researchers, the findings of the study could lead to the development of new MS prevention techniques.
Click here to visit the Multiple Sclerosis Quick Guide
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