07 Nov 2008
Discussion of sexual history, attitude and background could provide a way of evaluating diabetes risk, according to a new study.
Reported in the journal Disease Models & Mechanisms, the research involved the studying of glucose tolerance in field mice which are native to North America - Peromyscus.
Staff from the University of Cambridge in the UK chose two species of the animal which were closely related in terms of their genetics, but significantly different in their native environment and behavioural traits.
During the trials, it was found that handling the male mice and subjecting them to a placebo test, where glucose was replaced with saline, resulted in differences in blood sugar levels.
"Males of a calmer, more monogamous species had a higher level of stress hormones and a superior ability to regulate blood sugar, in comparison to males of a less calm, less monogamous species, or females of either species," the study says.
It was found that a genetic variance linked to the Y chromosome is responsible for the species-specific responses to stress in the male mice.
The researchers proposed superior blood sugar regulation is related to monogamy in mice, which could have implications for the treatment of diabetes in humans.
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